phys.org/news/2026-10-mechanism-parp1-dna-characterized-insight.html Mechanism behind PARP1-mediated DNA repair characterized, offering insight into targeted cancer therapy
St. Jude researchers found that PARP1 asymmetrically evicts two histone proteins beside DNA damage, converting a nucleosome into a hexasome that recruits repair proteins. The finding suggests future inhibitors could target PARP1's remodeling activity instead of shutting down all PARP activity.
— via Phys.org
