When San Francisco (5-9) and Arizona (8-6) kick off at 4:30 p.m. ET, it'll be the first national NFL broadcast to take place exclusively on Amazon Prime Video and Twitch. There will be no traditional television broadcast on a classic channel, but instead a stream-only broadcast. Thanks to free trials discussed below, this game should be available to anyone who wants to watch it, albeit in a slightly different way than usual.

An important note before we get into more details: 49ers vs. Cardinals will be available for local broadcast in the teams' home markets. In San Francisco, the game can be seen on NBC affiliate KNTV, while in Arizona, it'll be on local Fox affiliate KSAZ

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