Updates Of all the lessons we’ve learned from this pandemic, the most significant is how unequal its effects have been
Coronavirus – latest updates
See all our coronavirus coverage
‘The pandemic has been a test of our self-interest, both as individuals and as nations.’ A volunteer in Bhopal has a swab sample taken during trials of India’s Bharat Biotech vaccine. Photograph: Sanjeev Gupta/EPA
If you wanted to run an experiment on Earth to understand human behaviour, the pandemic would be the perfect opportunity. In some people, the virus that causes Covid-19 has no symptoms. In others it leads to deadly disease. The virus pits the healthy against those with underlying health issues, and the young against the old. Infectious diseases can bind us together or drive us apart. Low-income countries know this too well; many face multiple outbreaks of infectious diseases each year. But richer countries such as Britain are still painfully learning that a virus doesn’t just attack the human body: it holds up a mirror to national weaknesses and runs havoc across society and the economy.
Across the world, the pandemic has resulted in a perverse “Hunger Games”, where countries have competed in mortality rate league tables while also trying to save their economies and cope with successive waves of this disease. In February and March, European governments chased down limited PPE stocks, ventilators, oxygen, out-of-stock reagents for their labs, and experimental steroids and drugs. The US was accused of stealing ventilators from Barbados, PPE from Germany and it bought up the rights to remdesivir, limiting the supply available to other countries. At the World Health Assembly in May, governments committed to sharing research products and working collectively to address Covid-19. But when governments were faced with tough decisions about how to share resources, their promises of cooperation broke down.
The pandemic has been a test of our self-interest, both as individuals and as nations. One of the key questions has been what responsibility richer countries owe towards poorer nations, particularly when it comes to ensuring the equitable distribution of a vaccine. Earlier this year, 171 countries pledged to take part in the Covax initiative, which aims to support the development and equitable distribution of 2bn vaccine doses before the end of 2021. But when the first vaccine proved successful, manufactured by Pfizer and BioNTech, richer countries bought up 80% of its doses.
In fact, one analysis by Oxfam found that even if all five of the most advanced vaccine candidates succeed, there would not be enough vaccine for most of the world’s people until 2022. This has always been the case in global health: whoever pays the highest price acquires the research products. The World Health Organization has actively tried to warn against this nationalistic approach, but in the end, words and pledges don’t amount to anything unless they are followed by action. It’s money and power that counts.
The same questions about selfishness can be asked of our commitment to each other at home. What responsibility does each of us have towards our communities? The pandemic has divided families, friends and neighbours over whether they’re willing to bend the rules to accommodate individual wishes, or make sacrifices with others in mind. The mixed reaction to summer holidays reflected this, as some people decided to travel to other countries, with the risk of transporting the virus with them, while others stayed put. In some schools, entire bubbles of children were sent home to isolate because one student in the bubble had been on holiday abroad and their parents had decided not to follow the 14-day quarantine rule.
Families have been split over the question of Christmas celebrations; whether it’s sensible to host multiple families at one gathering, or wait to delay festivities until the spring or summer when a mass vaccination programme is in motion. On many occasions, the virus has forced us to decide how comfortable we each are with particular risks, and to reevaluate others according to their own risk threshold. We may have become closer to some families who share our thinking, and distanced ourselves from others who have different approaches to the pandemic. In comparing our pre- and post-Covid selves, we’re perhaps at risk of overstating how much the pandemic has changed us: instead, it has simply shown each of us who we really are.
There were many bright moments of selflessness in 2020. Many people made huge personal sacrifices – none more so than the health workers who put their own lives at risk to treat patients needing care. Because of their occupation, healthcare workers are seven times more likely to get severe Covid-19 than other workers, and many turned up to work on wards in March and April without adequate PPE, ready to accept whatever came their way. Elsewhere, bus drivers, security guards, social care workers, cleaners, grocery store workers, mutual aid groups, and teachers all put the needs of running society above their own health and welfare. If anything this pandemic should give us cause to reflect who adds value to society and whether we are compensating these roles appropriately.
On the other hand, time and time again in Britain, we’ve seen that it is one rule for some people (the wealthy and powerful) and another rule for others (the rest of us). The government created a loophole in quarantine restrictions that allowed “high value” business travellers to skip the mandatory 14-day isolation period when arriving into the country. Celebrities have hosted private parties while the rest of us have avoided social gatherings and seeing our family and friends. Most memorable of all, the prime minister’s then chief adviser, Dominic Cummings, breached Covid rules but remained in his post.
Of all the lessons we’ve learned from this pandemic, the most significant is how unequal its effects have been. Wealth, it turns out, is the best shielding strategy from Covid-19. As poorer people crowded together in cramped housing, the rich escaped to their country retreats. Two of the largest risk factors for dying from Covid-19 are being from a deprived background and being from a minority-ethnic background, pointing to the underlying role of social inequalities, housing conditions and occupation.
Coronavirus – latest updates See all our coronavirus coverage ‘The pandemic has been a test of our self-interest, both as individuals and as nations.’ A volunteer in Bhopal has a swab sample taken during trials of India’s Bharat Biotech vaccine. Photograp (#295748) · Issues · GitLab.org / GitLab · GitLab
Our society’s recovery from this disease should be centred on building more equal, resilient societies, where people in all parts of the world have access to both protection from the disease and access to research developments. It all starts with government. At the end of a gruelling 11 months, I’m left with Abraham Lincoln’s words in my mind: the pandemic has shown that we need “government of the people, by the people, for the people” – not just government for the wealthy elite. Perhaps that’s the strongest legacy of Covid-19.
• Prof Devi Sridhar is chair of global public health at the University of Edinburgh
Exclusive: Antibody therapy could confer instant immunity to Covid-19 on at-risk groups
See all our coronavirus coverage
A ventilated coronavirus patient: doctors hope the antibody therapy can be given to inpatients. Photograph: Murdo MacLeod/The Guardian
Denis Campbell Health policy editor
Fri 25 Dec 2020 12.00 EST
1,016
British scientists are trialling a new drug that could prevent someone who has been exposed to coronavirus from going on to develop the disease Covid-19, which experts say could save many lives.
The antibody therapy would confer instant immunity against the disease and could be given as an emergency treatment to hospital inpatients and care home residents to help contain outbreaks.
People living in households where someone has caught Covid could be injected with the drug to ensure they do not become infected too. It could also be given to university students, among whom the virus has spread rapidly because they live, study and socialise together.
Dr Catherine Houlihan, a virologist at University College London Hospitals NHS trust (UCLH) who is leading a study called Storm Chaser into the drug, said: “If we can prove that this treatment works and prevent people who are exposed to the virus going on to develop Covid-19, it would be an exciting addition to the arsenal of weapons being developed to fight this dreadful virus.,”
The drug has been developed by UCLH and AstraZeneca, the pharmaceutical company that has also, along with Oxford University, created a vaccine that the Medicines and Healthcare products Regulatory Agency is expected to approve for use in Britain next week.
The team hope the trial shows that the cocktail of antibodies protects against Covid-19 for between six and 12 months. Trial participants are receiving it as two doses, one after the other. If it is approved, it would be offered to someone who has been exposed to Covid in the previous eight days.
It could be available as soon as March or April if it is approved by the medicines regulator after it has reviewed evidence from the study. The trial involves ULCH, several other British hospitals and a network of 100 sites globally. This month University College hospital became the first site in the world to recruit patients into the randomised control trial and give them the jab or a placebo.
“To date we have injected 10 participants — staff, students and other people — who were exposed to the virus at home, in a healthcare setting or student halls,” said Houlihan. She and colleagues would closely follow the participants to see which of them develop Covid-19.
The immediate protection that the drug promises could play a vital role in reducing the impact of the virus until everyone has been immunised. The vaccination programme is under way using the Pfizer/BioNTech jab and is expected to take until next summer.
NHS England accelerated the vaccine deployment this week after criticism from hospital bosses, GP leaders and the former health secretary Jeremy Hunt that it was taking too long.
“The advantage of this medicine is that it gives you immediate antibodies,” Houlihan said. “We could say to trial participants who have been exposed: yes, you can have the vaccine. But we wouldn’t be telling them that would protect them from the disease, because it’s too late by then [because the Pfizer and Oxford vaccines do not confer full immunity for around a month].”
Paul Hunter, a professor of medicine at the University of East Anglia who specialises in infectious diseases, said the new treatment could significantly reduce the death toll from Covid.
“If you are dealing with outbreaks in settings such as care homes, or if you have got patients who are particularly at risk of getting severe Covid, such as the elderly, then this could well save a lot of lives. Providing it’s borne out in phase 3 trials, it could play a big role in keeping alive people who would otherwise die. So it should be a big thing,” he said.
“If you had an outbreak in a care home, you might want to use these sorts of cocktails of antibodies to bring the outbreak under control as soon as possible by giving the drug to everybody in the care home — residents and staff — who hasn’t been vaccinated. Similarly, if you live with your elderly grandmother and you or someone else in the house gets infected, then you could give her this to protect her.”
The drug involves a long-acting antibody combination known as AZD7442, which has been developed by AstraZeneca. Rather than antibodies produced by the body to help fight an infection, AZD7442 uses monoclonal antibodies, which have been created in a laboratory.
In documents on a clinical trial that AstraZeneca has registered in the US, it explains that it is investigating “the efficacy of AZD7442 for the post-exposure prophylaxis of Covid-19 in adults. The Sars-CoV-2 spike protein contains the virus’s RBD [receptor-binding domain], which enables the virus to bind to receptors on human cells. By targeting this region of the virus’s spike protein, antibodies can block the virus’s attachment to human cells, and therefore is expected to block infection.”
In a separate trial, called Provent, UCLH is investigating whether the drug could also protect people with compromised immune systems, such as those undergoing chemotherapy for cancer, who have recently been exposed to the virus but have either not had a vaccine or in whom it has not resulted in immunity because of their underlying condition. Both the Provent and Storm Chaser trials are now in phase 3.
Dr Nicky Longley, an infectious diseases consultant at UCLH, who is leading the second study, said: “We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine. We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective.”
Both trials are being undertaken at UCLH’s new vaccine research centre, which is funded by the NHS’s research arm, the National Institute for Health Research, and led by Prof Vincenzo Libri.
Dr Richard Jarvis, a co-chair of the British Medical Association’s public health medicine committee, said: “For the vast majority of the population, vaccination offers the best protection against Covid-19, and NHS staff are working around the clock to administer this to as many vulnerable patients as possible in this first rollout wave.
“It’ll certainly be interesting to see if these trials are effective. But it’s important that any new treatments are thoroughly researched, scrutinised and, most importantly, safe before we consider introducing them.”
Exclusive: Antibody therapy could confer instant immunity to Covid-19 on at-risk groups
See all our coronavirus coverage
A ventilated coronavirus patient: doctors hope the antibody therapy can be given to inpatients. Photograph: Murdo MacLeod/The Guardian
Denis Campbell Health policy editor
Fri 25 Dec 2020 12.00 EST
1,016
British scientists are trialling a new drug that could prevent someone who has been exposed to coronavirus from going on to develop the disease Covid-19, which experts say could save many lives.
The antibody therapy would confer instant immunity against the disease and could be given as an emergency treatment to hospital inpatients and care home residents to help contain outbreaks.
People living in households where someone has caught Covid could be injected with the drug to ensure they do not become infected too. It could also be given to university students, among whom the virus has spread rapidly because they live, study and socialise together.
Dr Catherine Houlihan, a virologist at University College London Hospitals NHS trust (UCLH) who is leading a study called Storm Chaser into the drug, said: “If we can prove that this treatment works and prevent people who are exposed to the virus going on to develop Covid-19, it would be an exciting addition to the arsenal of weapons being developed to fight this dreadful virus.,”
The drug has been developed by UCLH and AstraZeneca, the pharmaceutical company that has also, along with Oxford University, created a vaccine that the Medicines and Healthcare products Regulatory Agency is expected to approve for use in Britain next week.
The team hope the trial shows that the cocktail of antibodies protects against Covid-19 for between six and 12 months. Trial participants are receiving it as two doses, one after the other. If it is approved, it would be offered to someone who has been exposed to Covid in the previous eight days.
It could be available as soon as March or April if it is approved by the medicines regulator after it has reviewed evidence from the study. The trial involves ULCH, several other British hospitals and a network of 100 sites globally. This month University College hospital became the first site in the world to recruit patients into the randomised control trial and give them the jab or a placebo.
“To date we have injected 10 participants — staff, students and other people — who were exposed to the virus at home, in a healthcare setting or student halls,” said Houlihan. She and colleagues would closely follow the participants to see which of them develop Covid-19.
The immediate protection that the drug promises could play a vital role in reducing the impact of the virus until everyone has been immunised. The vaccination programme is under way using the Pfizer/BioNTech jab and is expected to take until next summer.
NHS England accelerated the vaccine deployment this week after criticism from hospital bosses, GP leaders and the former health secretary Jeremy Hunt that it was taking too long.
“The advantage of this medicine is that it gives you immediate antibodies,” Houlihan said. “We could say to trial participants who have been exposed: yes, you can have the vaccine. But we wouldn’t be telling them that would protect them from the disease, because it’s too late by then [because the Pfizer and Oxford vaccines do not confer full immunity for around a month].”
Paul Hunter, a professor of medicine at the University of East Anglia who specialises in infectious diseases, said the new treatment could significantly reduce the death toll from Covid.
“If you are dealing with outbreaks in settings such as care homes, or if you have got patients who are particularly at risk of getting severe Covid, such as the elderly, then this could well save a lot of lives. Providing it’s borne out in phase 3 trials, it could play a big role in keeping alive people who would otherwise die. So it should be a big thing,” he said.
“If you had an outbreak in a care home, you might want to use these sorts of cocktails of antibodies to bring the outbreak under control as soon as possible by giving the drug to everybody in the care home — residents and staff — who hasn’t been vaccinated. Similarly, if you live with your elderly grandmother and you or someone else in the house gets infected, then you could give her this to protect her.”
The drug involves a long-acting antibody combination known as AZD7442, which has been developed by AstraZeneca. Rather than antibodies produced by the body to help fight an infection, AZD7442 uses monoclonal antibodies, which have been created in a laboratory.
In documents on a clinical trial that AstraZeneca has registered in the US, it explains that it is investigating “the efficacy of AZD7442 for the post-exposure prophylaxis of Covid-19 in adults. The Sars-CoV-2 spike protein contains the virus’s RBD [receptor-binding domain], which enables the virus to bind to receptors on human cells. By targeting this region of the virus’s spike protein, antibodies can block the virus’s attachment to human cells, and therefore is expected to block infection.”
In a separate trial, called Provent, UCLH is investigating whether the drug could also protect people with compromised immune systems, such as those undergoing chemotherapy for cancer, who have recently been exposed to the virus but have either not had a vaccine or in whom it has not resulted in immunity because of their underlying condition. Both the Provent and Storm Chaser trials are now in phase 3.
Dr Nicky Longley, an infectious diseases consultant at UCLH, who is leading the second study, said: “We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine. We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective.”
Both trials are being undertaken at UCLH’s new vaccine research centre, which is funded by the NHS’s research arm, the National Institute for Health Research, and led by Prof Vincenzo Libri.
Dr Richard Jarvis, a co-chair of the British Medical Association’s public health medicine committee, said: “For the vast majority of the population, vaccination offers the best protection against Covid-19, and NHS staff are working around the clock to administer this to as many vulnerable patients as possible in this first rollout wave.
“It’ll certainly be interesting to see if these trials are effective. But it’s important that any new treatments are thoroughly researched, scrutinised and, most importantly, safe before we consider introducing them.”
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Updates Of all the lessons we’ve learned from this pandemic, the most significant is how unequal its effects have been
Coronavirus – latest updates
See all our coronavirus coverage
‘The pandemic has been a test of our self-interest, both as individuals and as nations.’ A volunteer in Bhopal has a swab sample taken during trials of India’s Bharat Biotech vaccine. Photograph: Sanjeev Gupta/EPA
Fri 25 Dec 2020 08.00 EST
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If you wanted to run an experiment on Earth to understand human behaviour, the pandemic would be the perfect opportunity. In some people, the virus that causes Covid-19 has no symptoms. In others it leads to deadly disease. The virus pits the healthy against those with underlying health issues, and the young against the old. Infectious diseases can bind us together or drive us apart. Low-income countries know this too well; many face multiple outbreaks of infectious diseases each year. But richer countries such as Britain are still painfully learning that a virus doesn’t just attack the human body: it holds up a mirror to national weaknesses and runs havoc across society and the economy.
Across the world, the pandemic has resulted in a perverse “Hunger Games”, where countries have competed in mortality rate league tables while also trying to save their economies and cope with successive waves of this disease. In February and March, European governments chased down limited PPE stocks, ventilators, oxygen, out-of-stock reagents for their labs, and experimental steroids and drugs. The US was accused of stealing ventilators from Barbados, PPE from Germany and it bought up the rights to remdesivir, limiting the supply available to other countries. At the World Health Assembly in May, governments committed to sharing research products and working collectively to address Covid-19. But when governments were faced with tough decisions about how to share resources, their promises of cooperation broke down.
The pandemic has been a test of our self-interest, both as individuals and as nations. One of the key questions has been what responsibility richer countries owe towards poorer nations, particularly when it comes to ensuring the equitable distribution of a vaccine. Earlier this year, 171 countries pledged to take part in the Covax initiative, which aims to support the development and equitable distribution of 2bn vaccine doses before the end of 2021. But when the first vaccine proved successful, manufactured by Pfizer and BioNTech, richer countries bought up 80% of its doses.
In fact, one analysis by Oxfam found that even if all five of the most advanced vaccine candidates succeed, there would not be enough vaccine for most of the world’s people until 2022. This has always been the case in global health: whoever pays the highest price acquires the research products. The World Health Organization has actively tried to warn against this nationalistic approach, but in the end, words and pledges don’t amount to anything unless they are followed by action. It’s money and power that counts.
The same questions about selfishness can be asked of our commitment to each other at home. What responsibility does each of us have towards our communities? The pandemic has divided families, friends and neighbours over whether they’re willing to bend the rules to accommodate individual wishes, or make sacrifices with others in mind. The mixed reaction to summer holidays reflected this, as some people decided to travel to other countries, with the risk of transporting the virus with them, while others stayed put. In some schools, entire bubbles of children were sent home to isolate because one student in the bubble had been on holiday abroad and their parents had decided not to follow the 14-day quarantine rule.
Families have been split over the question of Christmas celebrations; whether it’s sensible to host multiple families at one gathering, or wait to delay festivities until the spring or summer when a mass vaccination programme is in motion. On many occasions, the virus has forced us to decide how comfortable we each are with particular risks, and to reevaluate others according to their own risk threshold. We may have become closer to some families who share our thinking, and distanced ourselves from others who have different approaches to the pandemic. In comparing our pre- and post-Covid selves, we’re perhaps at risk of overstating how much the pandemic has changed us: instead, it has simply shown each of us who we really are.
There were many bright moments of selflessness in 2020. Many people made huge personal sacrifices – none more so than the health workers who put their own lives at risk to treat patients needing care. Because of their occupation, healthcare workers are seven times more likely to get severe Covid-19 than other workers, and many turned up to work on wards in March and April without adequate PPE, ready to accept whatever came their way. Elsewhere, bus drivers, security guards, social care workers, cleaners, grocery store workers, mutual aid groups, and teachers all put the needs of running society above their own health and welfare. If anything this pandemic should give us cause to reflect who adds value to society and whether we are compensating these roles appropriately.
On the other hand, time and time again in Britain, we’ve seen that it is one rule for some people (the wealthy and powerful) and another rule for others (the rest of us). The government created a loophole in quarantine restrictions that allowed “high value” business travellers to skip the mandatory 14-day isolation period when arriving into the country. Celebrities have hosted private parties while the rest of us have avoided social gatherings and seeing our family and friends. Most memorable of all, the prime minister’s then chief adviser, Dominic Cummings, breached Covid rules but remained in his post.
Of all the lessons we’ve learned from this pandemic, the most significant is how unequal its effects have been. Wealth, it turns out, is the best shielding strategy from Covid-19. As poorer people crowded together in cramped housing, the rich escaped to their country retreats. Two of the largest risk factors for dying from Covid-19 are being from a deprived background and being from a minority-ethnic background, pointing to the underlying role of social inequalities, housing conditions and occupation.
Coronavirus – latest updates See all our coronavirus coverage ‘The pandemic has been a test of our self-interest, both as individuals and as nations.’ A volunteer in Bhopal has a swab sample taken during trials of India’s Bharat Biotech vaccine. Photograp (#295748) · Issues · GitLab.org / GitLab · GitLab
Our society’s recovery from this disease should be centred on building more equal, resilient societies, where people in all parts of the world have access to both protection from the disease and access to research developments. It all starts with government. At the end of a gruelling 11 months, I’m left with Abraham Lincoln’s words in my mind: the pandemic has shown that we need “government of the people, by the people, for the people” – not just government for the wealthy elite. Perhaps that’s the strongest legacy of Covid-19.
• Prof Devi Sridhar is chair of global public health at the University of Edinburgh
Exclusive: Antibody therapy could confer instant immunity to Covid-19 on at-risk groups
See all our coronavirus coverage
A ventilated coronavirus patient: doctors hope the antibody therapy can be given to inpatients. Photograph: Murdo MacLeod/The Guardian
Denis Campbell Health policy editor
Fri 25 Dec 2020 12.00 EST
1,016
British scientists are trialling a new drug that could prevent someone who has been exposed to coronavirus from going on to develop the disease Covid-19, which experts say could save many lives.
The antibody therapy would confer instant immunity against the disease and could be given as an emergency treatment to hospital inpatients and care home residents to help contain outbreaks.
People living in households where someone has caught Covid could be injected with the drug to ensure they do not become infected too. It could also be given to university students, among whom the virus has spread rapidly because they live, study and socialise together.
Dr Catherine Houlihan, a virologist at University College London Hospitals NHS trust (UCLH) who is leading a study called Storm Chaser into the drug, said: “If we can prove that this treatment works and prevent people who are exposed to the virus going on to develop Covid-19, it would be an exciting addition to the arsenal of weapons being developed to fight this dreadful virus.,”
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The drug has been developed by UCLH and AstraZeneca, the pharmaceutical company that has also, along with Oxford University, created a vaccine that the Medicines and Healthcare products Regulatory Agency is expected to approve for use in Britain next week.
The team hope the trial shows that the cocktail of antibodies protects against Covid-19 for between six and 12 months. Trial participants are receiving it as two doses, one after the other. If it is approved, it would be offered to someone who has been exposed to Covid in the previous eight days.
It could be available as soon as March or April if it is approved by the medicines regulator after it has reviewed evidence from the study. The trial involves ULCH, several other British hospitals and a network of 100 sites globally. This month University College hospital became the first site in the world to recruit patients into the randomised control trial and give them the jab or a placebo.
“To date we have injected 10 participants — staff, students and other people — who were exposed to the virus at home, in a healthcare setting or student halls,” said Houlihan. She and colleagues would closely follow the participants to see which of them develop Covid-19.
The immediate protection that the drug promises could play a vital role in reducing the impact of the virus until everyone has been immunised. The vaccination programme is under way using the Pfizer/BioNTech jab and is expected to take until next summer.
NHS England accelerated the vaccine deployment this week after criticism from hospital bosses, GP leaders and the former health secretary Jeremy Hunt that it was taking too long.
“The advantage of this medicine is that it gives you immediate antibodies,” Houlihan said. “We could say to trial participants who have been exposed: yes, you can have the vaccine. But we wouldn’t be telling them that would protect them from the disease, because it’s too late by then [because the Pfizer and Oxford vaccines do not confer full immunity for around a month].”
Paul Hunter, a professor of medicine at the University of East Anglia who specialises in infectious diseases, said the new treatment could significantly reduce the death toll from Covid.
“If you are dealing with outbreaks in settings such as care homes, or if you have got patients who are particularly at risk of getting severe Covid, such as the elderly, then this could well save a lot of lives. Providing it’s borne out in phase 3 trials, it could play a big role in keeping alive people who would otherwise die. So it should be a big thing,” he said.
“If you had an outbreak in a care home, you might want to use these sorts of cocktails of antibodies to bring the outbreak under control as soon as possible by giving the drug to everybody in the care home — residents and staff — who hasn’t been vaccinated. Similarly, if you live with your elderly grandmother and you or someone else in the house gets infected, then you could give her this to protect her.”
The drug involves a long-acting antibody combination known as AZD7442, which has been developed by AstraZeneca. Rather than antibodies produced by the body to help fight an infection, AZD7442 uses monoclonal antibodies, which have been created in a laboratory.
In documents on a clinical trial that AstraZeneca has registered in the US, it explains that it is investigating “the efficacy of AZD7442 for the post-exposure prophylaxis of Covid-19 in adults. The Sars-CoV-2 spike protein contains the virus’s RBD [receptor-binding domain], which enables the virus to bind to receptors on human cells. By targeting this region of the virus’s spike protein, antibodies can block the virus’s attachment to human cells, and therefore is expected to block infection.”
In a separate trial, called Provent, UCLH is investigating whether the drug could also protect people with compromised immune systems, such as those undergoing chemotherapy for cancer, who have recently been exposed to the virus but have either not had a vaccine or in whom it has not resulted in immunity because of their underlying condition. Both the Provent and Storm Chaser trials are now in phase 3.
https://www.freitag.de/autoren/vikingsvssaints/uclh-is-investigating-whether/view
Dr Nicky Longley, an infectious diseases consultant at UCLH, who is leading the second study, said: “We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine. We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective.”
Both trials are being undertaken at UCLH’s new vaccine research centre, which is funded by the NHS’s research arm, the National Institute for Health Research, and led by Prof Vincenzo Libri.
Dr Richard Jarvis, a co-chair of the British Medical Association’s public health medicine committee, said: “For the vast majority of the population, vaccination offers the best protection against Covid-19, and NHS staff are working around the clock to administer this to as many vulnerable patients as possible in this first rollout wave.
“It’ll certainly be interesting to see if these trials are effective. But it’s important that any new treatments are thoroughly researched, scrutinised and, most importantly, safe before we consider introducing them.”
Exclusive: Antibody therapy could confer instant immunity to Covid-19 on at-risk groups
See all our coronavirus coverage
A ventilated coronavirus patient: doctors hope the antibody therapy can be given to inpatients. Photograph: Murdo MacLeod/The Guardian
Denis Campbell Health policy editor
Fri 25 Dec 2020 12.00 EST
1,016
British scientists are trialling a new drug that could prevent someone who has been exposed to coronavirus from going on to develop the disease Covid-19, which experts say could save many lives.
The antibody therapy would confer instant immunity against the disease and could be given as an emergency treatment to hospital inpatients and care home residents to help contain outbreaks.
People living in households where someone has caught Covid could be injected with the drug to ensure they do not become infected too. It could also be given to university students, among whom the virus has spread rapidly because they live, study and socialise together.
Dr Catherine Houlihan, a virologist at University College London Hospitals NHS trust (UCLH) who is leading a study called Storm Chaser into the drug, said: “If we can prove that this treatment works and prevent people who are exposed to the virus going on to develop Covid-19, it would be an exciting addition to the arsenal of weapons being developed to fight this dreadful virus.,”
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https://www.freitag.de/autoren/vikingsvssaints/vulnerable-patients-possible-rollout-wave/view
https://www.freitag.de/autoren/vikingsvssaints/post-exposure-prophylaxis-of-covid-19/view
https://jakwwqqw.medium.com/exclusive-antibody-therapy-could-confer-instant-immunity-to-covid-19-on-at-risk-groups-322f308067a1
https://jakwwqqw.medium.com/vulnerable-patients-as-possible-in-this-first-rollout-wave-covid-19-new-thought-2021-e93c82f1a89d
The drug has been developed by UCLH and AstraZeneca, the pharmaceutical company that has also, along with Oxford University, created a vaccine that the Medicines and Healthcare products Regulatory Agency is expected to approve for use in Britain next week.
The team hope the trial shows that the cocktail of antibodies protects against Covid-19 for between six and 12 months. Trial participants are receiving it as two doses, one after the other. If it is approved, it would be offered to someone who has been exposed to Covid in the previous eight days.
It could be available as soon as March or April if it is approved by the medicines regulator after it has reviewed evidence from the study. The trial involves ULCH, several other British hospitals and a network of 100 sites globally. This month University College hospital became the first site in the world to recruit patients into the randomised control trial and give them the jab or a placebo.
“To date we have injected 10 participants — staff, students and other people — who were exposed to the virus at home, in a healthcare setting or student halls,” said Houlihan. She and colleagues would closely follow the participants to see which of them develop Covid-19.
The immediate protection that the drug promises could play a vital role in reducing the impact of the virus until everyone has been immunised. The vaccination programme is under way using the Pfizer/BioNTech jab and is expected to take until next summer.
NHS England accelerated the vaccine deployment this week after criticism from hospital bosses, GP leaders and the former health secretary Jeremy Hunt that it was taking too long.
“The advantage of this medicine is that it gives you immediate antibodies,” Houlihan said. “We could say to trial participants who have been exposed: yes, you can have the vaccine. But we wouldn’t be telling them that would protect them from the disease, because it’s too late by then [because the Pfizer and Oxford vaccines do not confer full immunity for around a month].”
Paul Hunter, a professor of medicine at the University of East Anglia who specialises in infectious diseases, said the new treatment could significantly reduce the death toll from Covid.
“If you are dealing with outbreaks in settings such as care homes, or if you have got patients who are particularly at risk of getting severe Covid, such as the elderly, then this could well save a lot of lives. Providing it’s borne out in phase 3 trials, it could play a big role in keeping alive people who would otherwise die. So it should be a big thing,” he said.
“If you had an outbreak in a care home, you might want to use these sorts of cocktails of antibodies to bring the outbreak under control as soon as possible by giving the drug to everybody in the care home — residents and staff — who hasn’t been vaccinated. Similarly, if you live with your elderly grandmother and you or someone else in the house gets infected, then you could give her this to protect her.”
The drug involves a long-acting antibody combination known as AZD7442, which has been developed by AstraZeneca. Rather than antibodies produced by the body to help fight an infection, AZD7442 uses monoclonal antibodies, which have been created in a laboratory.
In documents on a clinical trial that AstraZeneca has registered in the US, it explains that it is investigating “the efficacy of AZD7442 for the post-exposure prophylaxis of Covid-19 in adults. The Sars-CoV-2 spike protein contains the virus’s RBD [receptor-binding domain], which enables the virus to bind to receptors on human cells. By targeting this region of the virus’s spike protein, antibodies can block the virus’s attachment to human cells, and therefore is expected to block infection.”
In a separate trial, called Provent, UCLH is investigating whether the drug could also protect people with compromised immune systems, such as those undergoing chemotherapy for cancer, who have recently been exposed to the virus but have either not had a vaccine or in whom it has not resulted in immunity because of their underlying condition. Both the Provent and Storm Chaser trials are now in phase 3.
https://www.freitag.de/autoren/vikingsvssaints/uclh-is-investigating-whether/view
Dr Nicky Longley, an infectious diseases consultant at UCLH, who is leading the second study, said: “We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine. We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective.”
Both trials are being undertaken at UCLH’s new vaccine research centre, which is funded by the NHS’s research arm, the National Institute for Health Research, and led by Prof Vincenzo Libri.
Dr Richard Jarvis, a co-chair of the British Medical Association’s public health medicine committee, said: “For the vast majority of the population, vaccination offers the best protection against Covid-19, and NHS staff are working around the clock to administer this to as many vulnerable patients as possible in this first rollout wave.
https://brainly.co.id/tugas/37255597
https://gitlab.com/gitlab-org/gitlab/-/issues/295755
https://www.freitag.de/autoren/vikingsvssaints/5e02583430ec30fc30c8306f30018cb491cd306a4e8b5b9f308465705b57306a/view
https://www.freitag.de/autoren/vikingsvssaints/immunity-because-their-underlying-condition/
https://gitlab.com/gitlab-org/gitlab/-/issues/295756
“It’ll certainly be interesting to see if these trials are effective. But it’s important that any new treatments are thoroughly researched, scrutinised and, most importantly, safe before we consider introducing them.”
https://www.freitag.de/autoren/kdsfwefsdkfwe/vdaswfdsafdsfvsd/
https://www.freitag.de/autoren/kdsfwefsdkfwe/as-elton-john-sang-saturday-night2019s/
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