https://www.sciencedaily.com/releases/2019/12/191204144848.htm

Now, a new Tel Aviv University study proposes a radically simple and efficient way of calculating entropy -- and it probably exists on your own computer.

"We discovered a way to calculate entropy using a standard compression algorithm like the zip software we all have on our computers," explains Prof. Roy Beck of TAU's School of Physics and Astronomy. "Supercomputers are used today to simulate the folding or misfolding of proteins in diseased states. Our study demonstrated that by using a standard compression algorithm, we can provide new insights into the physical properties of these proteins by calculating their entropy values using a compression algorithm.